Summary: Model-based Analysis for ChIP-Seq #Summary(pl.UTF-8): - Name: MACS Version: 1.4.1 Release: 1 License: Artistic Group: Development/Languages/Python # user and password are "publicly" visible on the web page (ROT13) Source0: http://macs:chipseq@liulab.dfci.harvard.edu/MACS/src/%{name}-%{version}.tar.gz # Source0-md5: 0b6490e37265d485e387b8323e810d3d URL: http://liulab.dfci.harvard.edu/MACS/ BuildRequires: python-distribute BuildRequires: rpm-pythonprov BuildRequires: rpmbuild(macros) >= 1.710 Requires: python-modules BuildArch: noarch BuildRoot: %{tmpdir}/%{name}-%{version}-root-%(id -u -n) %description Next generation parallel sequencing technologies made chromatin immunoprecipitation followed by sequencing (ChIP-Seq) a popular strategy to study genome-wide protein-DNA interactions, while creating challenges for analysis algorithms. We present Model-based Analysis of ChIP-Seq (MACS) on short reads sequencers such as Genome Analyzer (Illumina / Solexa). MACS empirically models the length of the sequenced ChIP fragments, which tends to be shorter than sonication or library construction size estimates, and uses it to improve the spatial resolution of predicted binding sites. MACS also uses a dynamic Poisson distribution to effectively capture local biases in the genome sequence, allowing for more sensitive and robust prediction. MACS compares favorably to existing ChIP-Seq peak-finding algorithms, is publicly available open source, and can be used for ChIP-Seq with or without control samples. #%description -l pl.UTF-8 %prep %setup -q # fix #!/usr/bin/env python -> #!/usr/bin/python: %{__sed} -i -e '1s,^#!.*python,#!%{__python},' bin/* setup.py %build %py_build %install rm -rf $RPM_BUILD_ROOT %py_install %py_ocomp $RPM_BUILD_ROOT%{py_sitescriptdir} %py_comp $RPM_BUILD_ROOT%{py_sitescriptdir} %py_postclean %clean rm -rf $RPM_BUILD_ROOT %files %defattr(644,root,root,755) %doc ChangeLog NEW_IN_MACS14 README %attr(755,root,root) %{_bindir}/* %dir %{py_sitescriptdir}/MACS14 %dir %{py_sitescriptdir}/MACS14/IO %{py_sitescriptdir}/MACS14/*.py[co] %{py_sitescriptdir}/MACS14/IO/*.py[co] %if "%{py_ver}" > "2.4" %{py_sitescriptdir}/MACS-*.egg-info %endif